SiSaf Ltd

SiSaf Ltd is a UK-based biopharmaceutical company founded in 2006, specializing in RNA therapeutics. The company is headquartered in Guildford, England, and focuses on its proprietary Bio-Courier® delivery platform. This innovative platform combines bioabsorbable silicon with organic materials to enhance the stability, solubility, safety, targeting, and transfection efficiency of nucleic acids, including siRNA.

SiSaf has developed a robust pipeline of siRNA therapeutics aimed at treating rare genetic disorders, skeletal conditions, and oncology. Its lead programs include treatments for Osteopetrosis and corneal dystrophies, with additional projects targeting conditions such as achondroplasia and pancreatic cancer. The company operates fully integrated research labs and manufacturing facilities, allowing for efficient nucleic acid loading without the need for ultra-cold storage. SiSaf collaborates with partners like Avellino Labs USA and the University of L’Aquila, Italy, to advance its research and development efforts.