Motif Neurotech

Motif Neurotech is a Houston-based company that specializes in therapeutic brain-computer interfaces (BCI). Founded in 2022, it emerged from Jacob Robinson's lab at Rice University. The company is dedicated to developing minimally invasive bioelectronic implants aimed at monitoring and treating severe mental health conditions, particularly treatment-resistant depression (TRD).

Motif's flagship product, DOT, is the world's smallest implantable brain stimulator, designed to stimulate brain tissue without direct contact. This millimeter-sized device is implanted through a quick outpatient procedure and works in conjunction with a wearable headset for wireless communication and programming. DOT records brain activity and delivers targeted stimulation to help alleviate symptoms of TRD, making it a promising option for patients who have not responded to traditional treatments. The company is also focused on advancing a range of neural devices for various mental health applications and emphasizes patient involvement through clinical trials and advisory boards.