Upstream Lab is a non-profit research organization located at the MAP Centre for Urban Health Solutions in Toronto, Canada. Founded in 2016 by Dr. Andrew Pinto, the lab aims to improve population health by addressing social determinants of health (SDOH) such as income inequality, housing instability, and food insecurity. It employs a Learning Health System framework that combines data analytics and community engagement to promote systemic change.

The lab conducts various research initiatives, including developing screening tools to identify social risks in healthcare settings and implementing programs like the SPARK study, which connects patients to social resources. Upstream Lab also focuses on community and policy-level interventions, examining working conditions for personal support workers and improving employment access for individuals living with HIV. Additionally, it utilizes AI and big data to predict health risks and optimize healthcare delivery, producing research publications and policy frameworks to integrate social care into health systems.